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In the present study, natural gums (Hibiscus rosa-sinensis mucilage and Modified gum karaya) were investigated as superdisintegrants for use in immediate release tablet formulations containing olanzapine. Immediate release tablets of olanzapine were formulated using different concentrations (2, 3, 4, 5) of natural superdisintegrant viz; Hibiscus rosa - sinensis mucilage and modified gum karaya. Prepared tablets were evaluated for thickness, hardness, friability, uniformity of weight, disintegration time, wetting time and dissolution study. The formulated tablets had good appearance and better drug release properties. Modified gum karaya showed shorter disintegration time and showed 100% release is selected as optimized formulation. Immediate release tablet formulations containing modified gum karaya showed better dissolution efficiency property than the most widely used synthetic superdisintegrants. The dissolution rate followed first-order kinetics as the graphs drawn between log % drug unreleased vs time were found to be linear. The dissolution rate of Olanzapine was found to be effected by the concentration of the superdisintegrant used in the preparation of tablets. The formulation (F4) prepared with 5%w/w of modified gum karaya was offered relatively rapid release of Olanzapine when compared with other concentrations employed in this investigation. The difference factor (f1) and similarity factor (f2) were calculated for marketed formulation and for formulations prepared with modified gum karaya. The difference factor (f1) and similarity factor (f2) were found to be 12 and 68 respectively. Similarity factor (f2) is more than 50 and difference factor (f1) is less than 15, hence dissolution profiles are found to be similar.

Keywords

Olanzapine, Modified Gum Karaya, Hibiscus Rosa-Sinesis, Crospovidone.

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